The Ophelia or Optimizing Health Literacy and Access to Health Services process is a practical tool for effective health promotion program delivery with a multi-sector and pragmatic approach to design interventions. Through the use of a needs assessment and community profiling, vignettes and hypothetical personas were used in focused group discussions and workshops aimed at co-creating intervention ideas with stakeholders. Rapid realist reviews were then done to check for the feasibility of said interventions. This was adapted in a pilot community in Leyte, Philippines and was able to ensure health promotion interventions were designed with community resources, wisdom of immersed public health practitioners, and addressed community needs.