This is a cross-sectional study that aimed to evaluate the health status of jeepney drivers relative to their exposure to PM2.5 (particulate pollution composed of solid and liquid droplets with a diameter ≤ 2.5 µm). The study focused on cardiovascular and pulmonary parameters (i.e., health outcomes such as heart rate, blood pressure, oxygen saturation, and peak expiratory flow volume) and used real-time PM2.5 personal exposure measurements using portable 2.5M devices. Results showed that short-term exposure to PM2.5 can possibly lead to significant changes in heart and lung parameters, and the significant contribution of traffic. This called for vigilance in monitoring vehicle compliance to emission standards and a shift to efficient and cleaner mass transport.